Too bad for his assailant, five thousand years of living, dying, and keen paranoia means that Methos isn't quite as bad off as he seems; gut shots are awful, but so is having an axe stuck in your skull, for instance.

He won't be able to dodge, but turn and get his knife in the bastard's kidney? Hell. Yes.

And then the blackness of unconsciousness overcomes him, and he just hopes that he actually wakes up. This would be the stupidest way to die forever.